The SIRT6 Polyclonal Antibody (CAB7416) is an essential tool for researchers studying SIRT6, a key protein involved in cellular metabolism and aging processes. SIRT6, a member of the sirtuin family of proteins, is known for its role in DNA repair, genomic stability, and regulation of glucose and lipid metabolism.This antibody, produced in rabbits, is highly specific and sensitive for detecting SIRT6 in human samples. It has been validated for use in Western blotting applications, enabling researchers to visualize and quantify SIRT6 protein expression in different cell types and tissues.
With its ability to specifically target SIRT6, this polyclonal antibody is indispensable for studies in cell biology, aging research, and metabolic disorders. Investigating the functions and regulatory mechanisms of SIRT6 can provide crucial insights into aging-related diseases, metabolic conditions, and potential therapeutic interventions targeting this important protein.Overall, the SIRT6 Polyclonal Antibody (CAB7416) is a valuable tool for researchers looking to deepen their understanding of SIRT6 biology and its implications for human health and disease.
Product Name:
SIRT6 Rabbit Polyclonal Antibody
SKU:
CAB7416
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-294 of mouse SIRT6 (NP_001156902.1).
Enables several functions, including NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); and transcription corepressor activity. Involved in several processes, including cellular protein modification process; negative regulation of nucleobase-containing compound metabolic process; and positive regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6).
Purification Method:
Affinity purification
Gene ID:
50721
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SIRT6 antibody (CAB7416) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
