The SIRT4 Polyclonal Antibody (CAB7585) is a valuable tool for researchers studying SIRT4, a protein known for its role in regulating cellular metabolism and stress responses. This antibody, generated in rabbits, specifically targets human samples and is validated for use in Western blot applications. By binding to the SIRT4 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for studies in metabolic diseases, aging, and cancer research.SIRT4 is a member of the sirtuin family of proteins, known for their involvement in cellular processes such as energy production, DNA repair, and gene expression.
Specifically, SIRT4 has been linked to the regulation of mitochondrial function, glucose, and lipid metabolism, as well as response to oxidative stress. Understanding the role of SIRT4 in these pathways is essential for developing targeted therapies for metabolic disorders and age-related diseases.Overall, the SIRT4 Polyclonal Antibody is a valuable tool for researchers seeking to elucidate the functions and mechanisms of SIRT4 in various biological processes. Its high specificity and sensitivity make it an indispensable asset for studies aiming to uncover the intricate roles of SIRT4 in health and disease.
Product Name:
SIRT4 Rabbit Polyclonal Antibody
SKU:
CAB7585
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-313 of human SIRT4 (NP_036372.1).
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Purification Method:
Affinity purification
Gene ID:
23409
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SIRT4 Rabbit pAb (CAB7585) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
