The SIRT3 Polyclonal Antibody (CAB17113) is a valuable tool for research involving SIRT3, a key protein involved in regulating cellular metabolism and stress responses. This rabbit-raised antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to SIRT3, this antibody enables precise detection and analysis of this important protein in a variety of cell types.SIRT3, a member of the sirtuin family of proteins, plays a crucial role in maintaining cellular homeostasis by regulating processes such as mitochondrial function, oxidative stress response, and metabolism.
Dysregulation of SIRT3 has been linked to various age-related diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. As such, understanding the function and activity of SIRT3 is essential for developing targeted therapies in these areas of research.The SIRT3 Polyclonal Antibody is a reliable tool for investigating the role of SIRT3 in these disease contexts, as well as its potential as a therapeutic target. Researchers in the fields of biochemistry, cell biology, and molecular biology will find this antibody to be an essential component of their experimental toolkit.
Antibody Name:
Anti-SIRT3 Antibody
Antibody SKU:
CAB17113
Antibody Size:
20uL, 50uL, 100uL
Application:
WB IHC IF
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-130 of human SIRT3 (NP_036371.1).
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
