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SIRT3 Polyclonal Antibody (CAB21417)

SKU:
CAB21417
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

SIRT3 Polyclonal Antibody (CAB21417)

The SIRT3 Polyclonal Antibody (CAB21417) is an essential tool for researchers studying SIRT3, a key protein involved in cellular metabolism and longevity regulation. This antibody, produced in rabbits, shows high specificity for human samples and is validated for use in Western blot applications. By binding to the SIRT3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of aging, metabolism, and age-related diseases.SIRT3, a member of the sirtuin family of proteins, has been linked to the regulation of mitochondrial function, oxidative stress response, and energy metabolism.

Its role in promoting cellular homeostasis and protection against age-related decline has sparked interest in its potential therapeutic applications for diseases such as diabetes, neurodegenerative disorders, and cardiovascular conditions. By studying the expression and activity of SIRT3, researchers can gain insights into the molecular mechanisms underlying these age-related pathologies and potentially develop novel interventions to target them.

Product Name:SIRT3 Polyclonal Antibody
Product Code:CAB21417
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, 293T, Hep G2
Cellular Location:Mitochondrion matrix

SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 299-399 of human SIRT3 (NP_036371.1).
Sequence:PQRFL LHVVD FPMAD LLLIL GTSLE VEPFA SLTEA VRSSV PRLLI NRDLV GPLAW HPRSR DVAQL GDVVH GVESL VELLG WTEEM RDLVQ RETGK LDGPD K
Synonyms:SIR2L3
Calculated MW:44kDa
Observed MW:28kDa

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