The SIRT3 Monoclonal Antibody is a powerful tool for researchers studying the Sirtuin 3 (SIRT3) protein, a key player in cellular metabolism and aging. This antibody is specifically designed to target SIRT3 in human samples, allowing for precise detection and analysis in Western blot applications.SIRT3 is a member of the sirtuin family of proteins, known for their role in regulating energy metabolism and stress responses. As a mitochondrial deacetylase, SIRT3 plays a crucial role in maintaining mitochondrial function and protecting cells from oxidative damage. Dysregulation of SIRT3 has been linked to various age-related diseases, making it a promising target for therapeutic interventions.
By using the SIRT3 Monoclonal Antibody, researchers can gain insight into the role of SIRT3 in various cellular processes, including metabolism, stress response, and aging. This antibody offers high specificity and sensitivity, making it a valuable tool for studies in fields such as biochemistry, molecular biology, and aging research. Understanding the function of SIRT3 may lead to the development of novel treatments for age-related diseases and metabolic disorders.
Product Name:
SIRT3 Monoclonal Antibody
SKU:
CAB22409
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-399 of human SIRT3 (NP_036371.1).
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control.
Purification Method:
Affinity purification
Gene ID:
23410
Clone Number:
ARC51535
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SIRT3 antibody (CAB22409) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
