The SIRT2 Polyclonal Antibody (CAB14109) is a vital tool for researchers studying SIRT2, a member of the sirtuin family of proteins involved in various cellular processes, including metabolism, stress response, and aging. This antibody, developed using rabbits, exhibits high specificity to human samples and has been validated for use in Western blotting applications. By targeting the SIRT2 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it a versatile tool for investigations in the fields of cell biology and aging research.SIRT2, a NAD-dependent deacetylase enzyme, plays a crucial role in regulating diverse cellular functions, such as gene expression, DNA repair, and cell cycle progression.
Its involvement in numerous physiological and pathological processes makes it a key target for research on age-related diseases, neurodegeneration, and metabolic disorders. Understanding the mechanisms underlying SIRT2 activity is essential for developing interventions that can potentially modulate cellular aging and metabolic health.In summary, the SIRT2 Polyclonal Antibody (CAB14109) offers researchers a reliable means to explore the functions and mechanisms of SIRT2 in cellular processes and disease pathogenesis. With its high specificity and versatility, this antibody is a valuable asset for advancing scientific understanding in the fields of cell biology, aging, and metabolic health.
Product Name:
SIRT2 Rabbit Polyclonal Antibody
SKU:
CAB14109
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-350 of human SIRT2 (NP_036369.2).
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Purification Method:
Affinity purification
Gene ID:
22933
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SIRT2 antibody (CAB14109) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
