SIRPB1 Antibody (PACO46202)
- SKU:
- PACO46202
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SIRPB1 Antibody (PACO46202)
The SIRPB1 Polyclonal Antibody (PAC046202) is a valuable tool for researchers studying the SIRPB1 protein, which is involved in immune regulation, specifically inhibiting immune responses. This antibody is raised in rabbits and has high reactivity with human samples, making it suitable for a variety of research applications.The SIRPB1 antibody is validated for use in Western blotting, enabling the detection and analysis of the SIRPB1 protein in different cell types. This makes it an excellent choice for studies in immunology, cancer research, and other fields where understanding immune regulation is crucial.
SIRPB1, also known as signal-regulatory protein beta 1, plays a key role in modulating immune responses and maintaining immune homeostasis. Its function in regulating inflammation and immune reactions makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By studying the activity of SIRPB1, researchers can gain insights that may lead to the development of new therapies that manipulate immune function for therapeutic purposes.
| Antibody Name: | SIRPB1 Antibody (PACO46202) |
| Antibody SKU: | PACO46202 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Signal-regulatory protein beta-1 protein (30-371AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: SIRPB1 antibody at 6µg/ml. Lane 1: A549 whole cell lysate. Lane 2: PC-3 whole cell lysate. Lane 3: A375 whole cell lysate. Lane 4: Mouse heart tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44, 20 kDa. Observed band size: 44 kDa.. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO46202 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO46202 at dilution of 1:100. |
| Background: | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. |
| Synonyms: | Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b), SIRPB1 |
| UniProt Protein Function: | SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | O00241 |
| NCBI GenInfo Identifier: | 311033545 |
| NCBI Gene ID: | 10326 |
| NCBI Accession: | O00241.5 |
| UniProt Secondary Accession: | O00241,Q5TFQ9, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0, A6NLM2 B2R8V0 |
| UniProt Related Accession: | O00241,Q5TFQ8, O00241 |
| Molecular Weight: | 43,359 Da |
| NCBI Full Name: | Signal-regulatory protein beta-1 |
| NCBI Synonym Full Names: | signal regulatory protein beta 1 |
| NCBI Official Symbol: | SIRPB1Â Â |
| NCBI Official Synonym Symbols: | CD172b; SIRP-BETA-1Â Â |
| NCBI Protein Information: | signal-regulatory protein beta-1 |
| UniProt Protein Name: | Signal-regulatory protein beta-1 |
| UniProt Synonym Protein Names: | CD172 antigen-like family member B; CD_antigen: CD172b |
| Protein Family: | Signal-regulatory protein |
| UniProt Gene Name: | SIRPB1Â Â |
| UniProt Entry Name: | SIRB1_HUMAN |
| Antibodies |
| SIRPB1 Antibody (PACO00549) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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