The SIRPB1 Polyclonal Antibody (PAC022613) is a valuable tool for researchers studying the SIRPB1 protein, a cell surface receptor involved in immune regulation. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the SIRPB1 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.SIRPB1, also known as signal-regulatory protein beta 1, plays a crucial role in immune response modulation by regulating signaling pathways that control immune cell activation.
Its involvement in immune regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of SIRPB1 is essential for developing therapies that modulate immune responses effectively in these disease contexts.Overall, the SIRPB1 Polyclonal Antibody (PAC022613) is a valuable tool for researchers looking to study the role of SIRPB1 in immune regulation and its implications for various disease states.
Antibody Name:
SIRPB1 Antibody (PACO22613)
Antibody SKU:
PACO22613
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SIRPB1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HuvEc cells, COLO cells and HeLa cells, using SIRPB1 antibody.
Background:
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
Synonyms:
SIRP-beta-1; CD172b antigen;
UniProt Protein Function:
SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
