The SIRPB1 Polyclonal Antibody (PACO12218) is a valuable tool for studying the SIRPB1 protein, a member of the signal regulatory protein (SIRP) family that plays a role in immune regulation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications.SIRPB1 is known to modulate immune responses by interacting with ligands such as CD47, leading to the inhibition of phagocytosis and other immune functions.
Research involving SIRPB1 is important for understanding its role in immune regulation and its potential as a therapeutic target in diseases like cancer and autoimmune disorders.By using the SIRPB1 Polyclonal Antibody (PACO12218), researchers can detect and analyze SIRPB1 expression in various cell types, helping to advance our knowledge of immune regulation and potentially leading to the development of novel treatment strategies.
signal-regulatory protein β 1;SIRPB1;CD172b;DKFZp686A05192;FLJ26614;SIRP-BETA-1 ;
UniProt Protein Function:
SIRPB1 iso3: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
