The SIRPB1 Polyclonal Antibody (PACO00549) is a valuable tool for researchers studying the SIRPB1 protein, an immune checkpoint receptor involved in regulating immune responses. This antibody, produced through rabbit immunization, is highly specific to human samples and has been validated for use in Western blot applications.SIRPB1, also known as Signal Regulatory Protein Beta 1, plays a crucial role in modulating immune cell activation and tolerance. Its function in immune regulation makes it a promising target for research in various areas, including immunology and cancer biology. By binding to the SIRPB1 protein, this antibody enables accurate detection and analysis in different cell types, making it an ideal choice for studies investigating immune response mechanisms and potential therapeutic interventions.
Overall, the SIRPB1 Polyclonal Antibody is a reliable tool for researchers looking to explore the role of SIRPB1 in immune regulation and its implications in disease conditions such as cancer and inflammation. Its specificity and sensitivity make it a valuable asset for elucidating the functions and therapeutic potential of SIRPB1 in various research settings.
Antibody Name:
SIRPB1 Antibody
Antibody SKU:
PACO00549
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human CD172b.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SIRPB1; Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD antigen CD172b
UniProt Protein Function:
SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
