CD172a/SIRPα Rabbit Polyclonal Antibody (CAB9001)
- SKU:
- CAB9001
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | CD172a/SIRPα Rabbit Polyclonal Antibody |
SKU: | CAB9001 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-375 of human CD172a/SIRPα (NP_542970.1). |
Sequence: | EDVH SQVI CEVA HVTL QGDP LRGT ANLS ETIR VPPT LEVT QQPV RAEN QVNV TCQV RKFY PQRL QLTW LENG NVSR TETA STVT ENKD GTYN WMSW LLVN VSAH RDDV KLTC QVEH DGQP AVSK SHDL KVSA HPKE QGSN TAAE NTGS NERN IYIV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; CD172a/SIRPα |
Positive Sample: | U-87MG,Jurkat,293T,LO2,Mouse brain,Mouse kidney,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 55kDa |
Observed MW: | 65kDa |
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Purification Method: | Affinity purification |
Gene ID: | 140885 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |