The SIRP Alpha Rabbit Monoclonal Antibody (CAB9545) is a specialized tool for researchers studying SIRP Alpha, a key surface receptor involved in immune regulation and cell signaling pathways. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the SIRP Alpha protein, allowing for the detection and analysis of this important molecule in various cell types.SIRP Alpha is known to play a crucial role in immune cell communication and the regulation of immune responses. Its involvement in modulating immune reactions makes it a promising target for research in immunology, cancer biology, and inflammatory diseases.
By accurately detecting and quantifying SIRP Alpha levels, researchers can gain insight into its function and potential therapeutic applications in these disease contexts.Overall, the SIRP Alpha Rabbit Monoclonal Antibody (CAB9545) is a valuable tool for scientists seeking to deepen their understanding of immune regulation and develop new strategies for treating immune-related disorders. Its high specificity and reliability make it an essential component of any study involving SIRP Alpha and its associated pathways.
Product Name:
CD172a/SIRPα Rabbit Monoclonal Antibody
SKU:
CAB9545
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 395-495 of human CD172a/SIRPα (P78324).
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Purification Method:
Affinity purification
Gene ID:
140885
Clone Number:
ARC1626
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD172a/SIRPα Rabbit mAb (CAB9545) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
