The SIPA1L2 Polyclonal Antibody (PACO12216) is a vital tool for research involving SIPA1L2, a protein associated with cell migration and invasion in cancer progression. The antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By binding specifically to SIPA1L2, this antibody enables the detection and analysis of the protein in various cell types, making it an excellent choice for studies in oncology and metastasis research.SIPA1L2, a member of the Signal-induced proliferation-associated 1 (SIPA1) family, is known to play a crucial role in regulating cell adhesion and motility, key processes in cancer metastasis.
Its involvement in promoting cancer cell invasion makes it a promising target for investigations into tumor progression and therapeutic interventions. Uncovering the mechanisms by which SIPA1L2 influences cancer spread is essential for developing strategies to inhibit metastatic growth and improve patient outcomes.
signal-induced proliferation-associated 1 like 2;SIPA1L2;FLJ23126;FLJ23632;KIAA1389;SPAL2 ;
UniProt Protein Function:
SIPA1L2: 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, RasChromosomal Location of Human Ortholog: 1q42.2Molecular Function: GTPase activator activity; protein bindingBiological Process: positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
