The SIPA1 Polyclonal Antibody (CAB12253) is a valuable tool for researchers studying the SIPA1 protein, which is involved in cell signaling and regulation of cell growth and migration. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SIPA1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a versatile tool for studies in cancer biology, cell signaling, and metastasis.SIPA1, also known as signal-induced proliferation-associated protein 1, plays a crucial role in various cellular processes, including cell proliferation, migration, and invasion.
Dysregulation of SIPA1 has been implicated in cancer development and progression, making it a promising target for cancer research and potential therapeutic interventions. Understanding the molecular mechanisms involving SIPA1 can provide valuable insights into the progression of various cancer types and aid in the development of targeted therapies. Overall, the SIPA1 Polyclonal Antibody is a valuable resource for researchers investigating the role of SIPA1 in cancer biology and cell signaling, offering reliable and specific detection of the protein in various experimental settings.
Product Name:
SIPA1 Rabbit Polyclonal Antibody
SKU:
CAB12253
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 763-1042 of human SIPA1 (NP_694985.29).
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Purification Method:
Affinity purification
Gene ID:
6494
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SIPA1 Rabbit pAb (CAB12253) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
