The Sin3A Monoclonal Antibody (CAB21966) is a powerful tool for researchers studying Sin3A, a transcriptional corepressor involved in gene regulation and chromatin remodeling. This monoclonal antibody, produced in mice, exhibits high specificity and sensitivity towards Sin3A and has been validated for use in immunofluorescence and immunohistochemistry applications.Sin3A plays a crucial role in epigenetic regulation by recruiting histone deacetylases to repress gene transcription. Dysregulation of Sin3A has been implicated in various diseases, including cancer and neurological disorders.
By targeting Sin3A with this monoclonal antibody, researchers can gain valuable insights into its function and potential therapeutic applications.This antibody is recommended for studies in molecular biology, cancer biology, and neuroscience, where understanding the role of Sin3A is essential for advancing our knowledge of transcriptional regulation and disease mechanisms. Its versatility and reliability make it a valuable asset for any research laboratory seeking to delve deeper into the complex world of epigenetics.
Product Name:
Sin3A Monoclonal Antibody
SKU:
CAB21966
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Sin3A (NP_056292.1).
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Purification Method:
Affinity purification
Gene ID:
25942
Clone Number:
ARC54250
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Sin3A antibody (CAB21966) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
