The SIN3A Polyclonal Antibody (CAB13928) is a valuable tool for researchers studying SIN3A, a critical transcriptional regulator involved in gene silencing and chromatin organization. This antibody, produced in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By binding to the SIN3A protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and epigenetics.SIN3A plays a key role in gene expression regulation by recruiting chromatin-modifying enzymes to specific genomic loci, impacting various cellular processes such as proliferation, differentiation, and apoptosis.
Dysregulation of SIN3A has been linked to several diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. Understanding the molecular mechanisms underlying SIN3A function is crucial for developing novel treatments that target these diseases at the genetic level.
Product Name:
SIN3A Rabbit Polyclonal Antibody
SKU:
CAB13928
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Sin3A (NP_056292.1).
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Purification Method:
Affinity purification
Gene ID:
25942
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of 293T cells, using Sin3A antibody (CAB13928) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
