The SIM2 Polyclonal Antibody (CAB15098) is a valuable tool for researchers studying the SIM2 protein, which plays a crucial role in regulating gene expression and neuronal development. This antibody, developed using rabbit immunization, is highly specific to human samples and has been validated for use in applications such as Western blotting.SIM2, a transcriptional regulator involved in brain development and function, has been implicated in various neurological disorders, making it a promising target for research in neuroscience and neurodegenerative diseases.
By detecting and analyzing the SIM2 protein in different cell types, this antibody enables researchers to further investigate its function and potential therapeutic implications.Understanding the role of SIM2 in gene regulation and neuronal processes is essential for gaining insights into neurological disorders and developing new treatment strategies. With its high reactivity and specificity, the SIM2 Polyclonal Antibody is a valuable tool for advancing research in this field.
Product Name:
SIM2 Rabbit Polyclonal Antibody
SKU:
CAB15098
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 342-525 of human SIM2 (NP_005060.1?).
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6493
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SIM2 Rabbit pAb (CAB15098) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
