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Siltuximab: Exploring IL-6 Inhibition in Castleman’s Disease and Research

Siltuximab: Exploring IL-6 Inhibition in Castleman’s Disease and Research

Quick Facts About Siltuximab

  • What is Siltuximab?

  • What is the mechanism of action for Siltuximab?

Siltuximab binds to IL-6, preventing it from interacting with its receptor and mitigating downstream pro-inflammatory signaling.

  • What are the clinical applications of Siltuximab?

1.) Understanding Siltuximab

What Makes Siltuximab Unique?

Siltuximab is designed to address the overproduction of IL-6, a hallmark in certain inflammatory and oncological conditions. By targeting IL-6, Siltuximab helps manage disorders driven by immune dysregulation, including idiopathic multicentric Castleman’s disease (iMCD).

2.) Mechanism of Action of Siltuximab

Siltuximab operates by binding to IL-6, neutralizing its activity. This inhibition reduces the cytokine storm often associated with inflammatory diseases and improves disease symptoms. Its effectiveness in MCD highlights its role in modulating the immune response.

3.) Clinical Applications of Siltuximab

Multicentric Castleman’s Disease

Siltuximab is the only FDA-approved treatment for MCD in HIV- and HHV-8-negative patients. It improves disease symptoms and quality of life by counteracting IL-6-driven inflammation.

Cytokine Release Syndrome (CRS)

Emerging studies suggest potential applications of Siltuximab in managing CRS, a complication of CAR-T therapy, although it is not yet standard for this use.

Oncology Research

Research continues to evaluate Siltuximab's role in conditions like multiple myeloma and other cancers, where IL-6 is implicated.

4.) Advancing Research with Siltuximab Biosimilar

How Biosimilars Transform Research


Our Siltuximab biosimilar is a powerful tool for research applications, providing cost-effective and reliable alternatives to original biologics.

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Siltuximab (Anti-IL6) Biosimilar Antibody
Antibody Type:Monoclonal Antibody
Protein:IL-6
Reactivity:Human
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Benefits of Siltuximab Biosimilar

  • Innovative Research: Supports exploration into IL-6-related pathways.
  • Cost-Effective: Offers an accessible option for non-clinical research purposes.
  • High-Quality Standards: Ensures reproducibility and reliability in experimental settings.

Disclaimer: The Siltuximab biosimilar is for research use only and not for clinical or therapeutic applications.

Discover Our Biosimilar Range

At Assay Genie, we specialize in providing high-quality biosimilars for research use! Check out our full biosimilar range to learn more.

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Wrote by Shanza Riaz

Shanza Riaz is a dedicated biologist and academic researcher with a strong passion for the life sciences. Currently pursuing a PhD, Shanza specializes in genetics and computational biology. Her work includes research on genetic variations in the Kruppel-like factor protein family and their role in metabolic disease development.
26th Nov 2024 Shanza Riaz

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