The SIK1 Polyclonal Antibody (CAB15247) is a valuable tool for researchers studying SIK1, a key protein involved in cellular signaling pathways and gene expression regulation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the SIK1 protein, this antibody enables precise detection and analysis of SIK1 in a variety of cell types, making it an essential component for studies in molecular biology and cell signaling research.
SIK1, also known as salt-inducible kinase 1, plays a crucial role in controlling cellular responses to stress and regulating gene expression in various physiological processes. Its function in cell signaling and gene transcription makes it a significant target for investigations into metabolism, immune response, and cancer development. Understanding the mechanisms of SIK1 activity is essential for developing targeted therapies that manipulate cellular signaling pathways for therapeutic purposes.
Product Name:
SIK1 Rabbit Polyclonal Antibody
SKU:
CAB15247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SIK1 (NP_775490.2).
This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30.
Purification Method:
Affinity purification
Gene ID:
150094
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SIK1 Rabbit pAb (CAB15247) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 150s.
