The Sigmar1 Polyclonal Antibody (CAB5479) is a valuable tool for researchers studying Sigmar1, a protein involved in a variety of cellular processes such as calcium signaling, cell proliferation, and apoptosis. The antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples and is validated for use in Western blot applications.Sigmar1, also known as sigma-1 receptor, is a versatile protein that has been implicated in neurodegenerative diseases, psychiatric disorders, and cancer. Its role in modulating cell signaling pathways and mitochondrial function makes it a promising target for therapeutic intervention in these conditions.
By using the Sigmar1 Polyclonal Antibody, researchers can effectively detect and analyze Sigmar1 protein expression in a wide range of cell types, aiding in the understanding of its biological functions and potential implications in disease pathology.This antibody is a valuable tool for immunology and cancer researchers looking to further explore the role of Sigmar1 in cellular processes and disease pathogenesis. Its high specificity and reactivity make it a reliable option for studying the intricate functions of Sigmar1 and its potential as a therapeutic target in various disease states.
Product Name:
SIGMAR1 Rabbit Polyclonal Antibody
SKU:
CAB5479
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 114-223 of human SIGMAR1 (NP_005857.1).
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
10280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SIGMAR1 Rabbit pAb (CAB5479) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
