The SIGMAR1 Polyclonal Antibody (CAB14837) is specifically designed for researchers studying SIGMAR1, a protein involved in various cellular functions, including regulation of cell growth, survival, and stress response. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SIGMAR1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for investigations in neuroscience and cancer research.
SIGMAR1, also known as sigma-1 receptor, plays a critical role in modulating cellular signaling pathways that influence neuronal activity, neuroplasticity, and neuroprotection. Its involvement in regulating stress responses and cell survival processes makes it a key target for studying neurodegenerative disorders, psychiatric diseases, and cancer progression. Understanding the functions of SIGMAR1 is crucial for developing therapies that target this protein for the treatment of neurological and oncological conditions.
Product Name:
SIGMAR1 Rabbit Polyclonal Antibody
SKU:
CAB14837
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 31-80 of human SIGMAR1 (NP_005857.1).
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
10280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using SIGMAR1 Rabbit pAb (CAB14837) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
