SIGLEC8 Rabbit Polyclonal Antibody (CAB10514)
- SKU:
- CAB10514
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SIGLEC8 Rabbit Polyclonal Antibody |
SKU: | CAB10514 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-363 of human Siglec-8 (NP_055257.2). |
Sequence: | MEGD RQYG DGYL LQVQ ELVT VQEG LCVH VPCS FSYP QDGW TDSD PVHG YWFR AGDR PYQD APVA TNNP DREV QAET QGRF QLLG DIWS NDCS LSIR DARK RDKG SYFF RLER GSMK WSYK SQLN YKTK QLSV FVTA LTHR PDIL ILGT LESG HSRN LTCS VPWA CKQG TPPM ISWI GASV SSPG PTTA RSSV LTLT PKPQ DHGT SLTC QVTL PGTG VTTT STVR LDVS YPPW NLTM TVFQ GDAT ASTA LGNG SSLS VLEG QSLR LVCA VNSN PPAR LSWT RGSL TLCP SRSS NPGL LELP RVHV RDEG EFTC RAQN AQGS QHIS LSLS LQNE GTGT SRPV SQVT LAA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SAF2; SIGLEC-8; SIGLEC8L; Siglec-8 |
Positive Sample: | HL-60,293T,Mouse liver,Rat blood |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 54kDa |
Observed MW: | 60kDa |
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).
Purification Method: | Affinity purification |
Gene ID: | 27181 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |