The Siglec1 Polyclonal Antibody (CAB17533) is a research tool designed for studying Siglec1, a cell surface molecule involved in immune regulation and host-pathogen interactions. This rabbit polyclonal antibody is highly specific and reacts with human samples, making it a reliable tool for research in immunology and infectious diseases.Siglec1, also known as Sialoadhesin or CD169, plays a crucial role in immune response modulation by binding to sialylated glycans on pathogens and triggering immune responses. Its expression on macrophages and dendritic cells makes it a key player in orchestrating immune surveillance and host defense mechanisms. By targeting Siglec1, researchers can explore its function in various cell types and pathological conditions, offering insights into new therapeutic strategies for infectious diseases and autoimmune disorders.
The Siglec1 Polyclonal Antibody is validated for use in Western blot applications, enabling detection and analysis of Siglec1 protein levels in different experimental settings. Its high specificity and sensitivity make it an invaluable tool for investigating the molecular mechanisms underlying immune responses and host-pathogen interactions. Start exploring the role of Siglec1 in immunology and infectious diseases with this reliable research antibody.
Product Name:
SIGLEC1 Rabbit Polyclonal Antibody
SKU:
CAB17533
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-300 of human SIGLEC1 (NP_075556.1).
early endosome, extracellular region, late endosome, plasma membrane
Calculated MW:
183kDa
Observed MW:
200kDa
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection.
Purification Method:
Affinity purification
Gene ID:
6614
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using SIGLEC1 Rabbit pAb (CAB17533) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
