The SIAH2 Polyclonal Antibody (CAB16211) is a valuable tool for researchers studying SIAH2, a protein involved in regulating cellular processes such as apoptosis and cell cycle progression. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SIAH2 protein, this antibody enables researchers to detect and analyze SIAH2 expression in a variety of cell types, making it well-suited for immunology and cancer research studies.SIAH2 is known to play a crucial role in controlling cellular responses to stress and promoting the degradation of specific target proteins involved in cell growth and survival.
Its involvement in these pathways makes it a promising target for investigating diseases such as cancer, where dysregulation of cellular processes can lead to uncontrolled growth and proliferation. By understanding the function of SIAH2, researchers can uncover potential therapeutic strategies for targeting this protein in the treatment of various diseases.
Product Name:
SIAH2 Rabbit Polyclonal Antibody
SKU:
CAB16211
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SIAH2 (NP_005058.3).
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.
Purification Method:
Affinity purification
Gene ID:
6478
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SKOV3 cells, using SIAH2 Rabbit pAb (CAB16211) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
