The SIAE Polyclonal Antibody (CAB13217) is a valuable tool for researchers studying the SIAE protein, an enzyme involved in immune regulation and autoimmune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding to the SIAE protein, it allows for precise detection and analysis in a variety of cell types, making it ideal for studies in immunology and autoimmune diseases.SIAE, also known as sialic acid acetylesterase, plays a crucial role in immune tolerance by regulating the levels of sialic acid on glycoproteins.
Dysregulation of SIAE has been linked to autoimmune diseases such as lupus and rheumatoid arthritis, making it an important target for therapeutic interventions. Understanding the function of SIAE is essential for developing targeted treatments that modulate immune responses and promote immune tolerance in autoimmune conditions.Overall, the SIAE Polyclonal Antibody (CAB13217) provides researchers with a reliable tool to investigate the role of SIAE in immune regulation and autoimmunity, paving the way for new insights and potential therapeutic strategies in the field.
Product Name:
SIAE Rabbit Polyclonal Antibody
SKU:
CAB13217
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-450 of human SIAE (NP_733746.1).
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54414
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SIAE Rabbit pAb (CAB13217) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
