UniProt Protein Function: | SHPRH: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.1.-; EC 3.6.4.-; EC 6.3.2.-; EC 6.3.2.19; Helicase; Ligase; Ubiquitin conjugating system; Ubiquitin ligaseChromosomal Location of Human Ortholog: 6q24.3Molecular Function: protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activityBiological Process: protein polyubiquitination; response to DNA damage stimulus |
UniProt Protein Details: | |
NCBI Summary: | SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q149N8 |
NCBI GenInfo Identifier: | 109734409 |
NCBI Gene ID: | 257218 |
NCBI Accession: | BC117686 |
UniProt Secondary Accession: | Q149N8,Q149N9, Q5VV79, Q68DS5, Q7Z5J5, Q8IVE8, Q8IWQ9 Q8N1S8, Q8NBR7 |
UniProt Related Accession: | Q149N8 |
Molecular Weight: | 54,339 Da |
NCBI Full Name: | Homo sapiens SNF2 histone linker PHD RING helicase, mRNA |
NCBI Synonym Full Names: | SNF2 histone linker PHD RING helicase |
NCBI Official Symbol: | SHPRHÂ Â |
NCBI Official Synonym Symbols: | bA545I5.2Â Â |
NCBI Protein Information: | E3 ubiquitin-protein ligase SHPRH |
UniProt Protein Name: | E3 ubiquitin-protein ligase SHPRH |
UniProt Synonym Protein Names: | SNF2, histone-linker, PHD and RING finger domain-containing helicase |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | SHPRHÂ Â |
UniProt Entry Name: | SHPRH_HUMAN |