The SHP2 Rabbit Monoclonal Antibody (CAB19112) is a powerful tool for researchers studying SHP2, a key cell signaling protein involved in various cellular processes, including cell growth, differentiation, and survival. This antibody, generated from rabbit monoclonal cells, is highly specific for SHP2 and is suitable for use in Western blot and immunohistochemistry applications.SHP2, also known as protein tyrosine phosphatase non-receptor type 11 (PTPN11), is a critical regulator of multiple signaling pathways, including the MAPK and PI3K-Akt pathways. Dysregulation of SHP2 has been implicated in a variety of diseases, including cancer, developmental disorders, and immune-related conditions.
By targeting SHP2, researchers can gain insights into the underlying mechanisms of these diseases and potentially develop new therapeutic strategies.The SHP2 Rabbit Monoclonal Antibody (CAB19112) provides researchers with a reliable tool for detecting and studying SHP2 in various cell types and tissues, making it an indispensable resource for studies in cancer biology, cell signaling, and drug development. Its high specificity and sensitivity make it an ideal choice for investigating the role of SHP2 in disease pathogenesis and identifying potential therapeutic targets.
Product Name:
SHP2 Rabbit Monoclonal Antibody
SKU:
CAB19112
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SHP2 (Q06124).
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Purification Method:
Affinity purification
Gene ID:
5781
Clone Number:
ARC2635
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using SHP2 Rabbit mAb (CAB19112) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
