The SHMT1 Polyclonal Antibody (CAB16974) is a valuable tool for research involving serine hydroxymethyltransferase 1 (SHMT1), a key enzyme in one-carbon metabolism. This antibody, generated in rabbits, is highly specific to SHMT1 and is validated for use in Western blot applications. It allows for the detection and analysis of SHMT1 in various cell types, making it an ideal choice for studies in metabolism, cancer research, and drug development.SHMT1 is essential for the conversion of serine to glycine, playing a critical role in nucleotide synthesis and DNA methylation. Dysregulation of SHMT1 has been implicated in various diseases, including cancer and neurodevelopmental disorders.
By understanding the function and regulation of SHMT1, researchers can uncover potential therapeutic targets and strategies for combating these conditions.Overall, the SHMT1 Polyclonal Antibody (CAB16974) offers researchers a reliable tool for investigating the role of SHMT1 in cellular metabolism and disease pathogenesis. Its specificity and sensitivity make it a valuable asset in advancing our understanding of one-carbon metabolism and its implications in health and disease.
Product Name:
SHMT1 Rabbit Polyclonal Antibody
SKU:
CAB16974
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 285-444 of human SHMT1 (NP_683718.1).
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6470
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of U-2 OS cells using SHMT1 Rabbit pAb (CAB16974) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
