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SHMT1 Monoclonal Antibody [PAT26E5AT] (CPAB0234)

SKU:
CPAB0234
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT26E5AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

SHMT1 Monoclonal Antibody [PAT26E5AT] (CPAB0234)

The SHMT1 Polyclonal Antibody (CPAB0234) is a powerful tool for researchers studying SHMT1, a key enzyme involved in one-carbon metabolism and nucleotide biosynthesis. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting SHMT1 in human samples, making it ideal for use in Western blot applications. By targeting the SHMT1 protein, this antibody enables researchers to investigate the role of SHMT1 in various cellular processes, including cancer progression, metabolic disorders, and developmental biology.

SHMT1, also known as serine hydroxymethyltransferase 1, plays a crucial role in maintaining cellular homeostasis by catalyzing the conversion of serine to glycine. Dysregulation of SHMT1 has been linked to various diseases, making it a promising therapeutic target for conditions like cancer and neurodegenerative disorders. Research using the SHMT1 Polyclonal Antibody can provide valuable insights into the biochemical functions of SHMT1 and its implications for human health.

Product Name:SHMT1 Antibody
Product Sku:CPAB0234
Size:5μg
Host Species:Mouse
Immunogen:Anti-human SHMT1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SHMT1 amino acids 1-483 purified from Ecoli.
Clone:PAT26E5AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:SHMT1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:SHMT1 is a member of the SHMT family. SHMT1 is the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme which catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5 10-methylene tetrahydrofolate. In addition, SHMT1 specifically provides one-carbon units for thymidylate biosynthesis, reduces methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate and inhibits SAM synthesis.
Synonyms:Serine hydroxymethyltransferase 1 (soluble), CSHMT, Glycine hydroxymethyltransferase, Serine methylase, 14 kDa protein, cytoplasmic serine hydroxymethyltransferase, serine hydroxymethyltransferase cytosolic, EC 2.1.2.1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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