The SHISA9 Antibody (PAC063767) is a valuable tool for researchers studying the SHISA9 protein, which has been implicated in various cellular processes, including neuronal development and synaptic transmission. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting experiments.SHISA9, also known as CKAMP44, is a transmembrane protein that plays a crucial role in regulating the activity of AMPA receptors, which are important for synaptic plasticity and learning and memory processes in the brain. Understanding the function of SHISA9 in these pathways is essential for furthering our knowledge of neurological disorders such as Alzheimer's disease and epilepsy, where disruptions in synaptic transmission are common.
By targeting the SHISA9 protein, researchers can gain valuable insights into the molecular mechanisms underlying neuronal communication and potentially uncover new therapeutic targets for neurological conditions. The SHISA9 Antibody (PAC063767) is a reliable tool for investigating the role of SHISA9 in these processes and advancing our understanding of brain function.
Antibody Name:
SHISA9 Antibody (PACO63767)
Antibody SKU:
PACO63767
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein shisa-9 protein (171-424AA)
Immunofluorescence staining of MCF-7 cells with PACO63767 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).
Synonyms:
Protein shisa-9, SHISA9
UniProt Protein Function:
SHISA9: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. Belongs to the shisa family. SHISA9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 16p13.12Cellular Component: ionotropic glutamate receptor complex; synapse; cell junctionBiological Process: regulation of short-term neuronal synaptic plasticity
