SHC1 Rabbit Polyclonal Antibody (CAB7725)
- SKU:
- CAB7725
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
Product Name: | SHC1 Rabbit Polyclonal Antibody |
SKU: | CAB7725 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human SHC1 (NP_001189788.1). |
Sequence: | PRDL FDMK PFED ALRV PPPP QSVS MAEQ LRGE PWFH GKLS RREA EALL QLNG DFLV REST TTPG QYVL TGLQ SGQP KHLL LVDP EGVV RTKD HRFE SVSH L |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | SHC; SHCA; SHC1 |
Positive Sample: | Jurkat,C6,Mouse lung,Mouse spleen,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion, Mitochondrion matrix. |
Calculated MW: | 63kDa |
Observed MW: | 66kDa |
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 6464 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |