The SHBG Polyclonal Antibody (CAB7450) is a valuable tool for researchers studying Sex Hormone-Binding Globulin (SHBG), a protein that binds to sex hormones such as testosterone and estrogen in the bloodstream. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SHBG protein, this antibody allows for the detection and analysis of SHBG levels in various cell types and tissues, making it an ideal choice for studies in endocrinology and reproductive health.SHBG plays a crucial role in regulating the levels of sex hormones in the body, impacting a range of physiological functions including reproductive health, bone density, and metabolic processes.
Abnormalities in SHBG levels have been associated with conditions such as polycystic ovary syndrome, hypogonadism, and metabolic disorders. By studying the expression and function of SHBG, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for treatment.Overall, the SHBG Polyclonal Antibody (CAB7450) provides researchers with a reliable tool for investigating the role of SHBG in health and disease, offering valuable insights into the intricate interplay between sex hormones and various physiological processes.
Product Name:
SHBG Rabbit Polyclonal Antibody
SKU:
CAB7450
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-170 of human SHBG (NP_001031.2).
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6462
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SHBG Rabbit pAb (CAB7450) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
