The Sharpin Polyclonal Antibody (CAB11714) is a crucial tool for researchers studying Sharpin, a protein involved in immune regulation and inflammation pathways. This antibody, produced in rabbits, is highly specific for human samples and has been validated for Western blot applications. By targeting the Sharpin protein, this antibody allows for the precise detection and analysis of Sharpin levels in various cell types, making it an essential tool for studies in immunology and inflammatory diseases.Sharpin, also known as shank-associated RH domain-interacting protein (SHARPIN), is a key player in the regulation of NF-κB signaling and the maintenance of immune homeostasis.
Dysregulation of Sharpin has been linked to autoimmune diseases, chronic inflammation, and cancer progression, highlighting its importance in immune response modulation. The Sharpin Polyclonal Antibody provides researchers with a reliable means to investigate the role of Sharpin in these pathological conditions and to potentially identify novel therapeutic targets for intervention.
Product Name:
SHARPIN Rabbit Polyclonal Antibody
SKU:
CAB11714
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SHARPIN (NP_112236.3).
Enables polyubiquitin modification-dependent protein binding activity. Involved in protein linear polyubiquitination and regulation of signal transduction. Located in cytosol. Part of LUBAC complex.
Purification Method:
Affinity purification
Gene ID:
81858
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SHARPIN Rabbit pAb (CAB11714) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
