The Shank1 Antibody (PACO12191) is a high-quality polyclonal antibody designed for research involving the Shank1 protein, a key player in synaptic function and neuronal development. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in applications such as Western blot and immunohistochemistry.Shank1 is a scaffolding protein found in the postsynaptic density of excitatory synapses in the brain, where it plays a crucial role in organizing synaptic proteins and regulating synaptic transmission. Dysregulation of Shank1 has been implicated in various neurodevelopmental and neuropsychiatric disorders, making it a promising target for research into conditions such as autism spectrum disorders and schizophrenia.
By specifically targeting Shank1, researchers can gain insights into its role in synaptic plasticity and neuronal connectivity, paving the way for potential therapeutic interventions targeting synaptic dysfunction in neurological and psychiatric diseases. The Shank1 Antibody (PACO12191) provides a reliable tool for studying Shank1 expression and function in various experimental settings, furthering our understanding of the molecular mechanisms underlying synaptic biology.
SH3 and multiple ankyrin repeat domains 1;SHANK1;SPANK-1;SSTRIP;synamon ;
UniProt Protein Function:
SHANK1: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19q13.3Cellular Component: postsynaptic membrane; neuron projection; membrane; dendrite; cytoplasm; dendritic spine; plasma membrane; excitatory synapse; ionotropic glutamate receptor complex; intracellular; cell junction; N-methyl-D-aspartate selective glutamate receptor complexMolecular Function: somatostatin receptor binding; protein C-terminus binding; ionotropic glutamate receptor binding; identical protein binding; protein binding; protein complex binding; GKAP/Homer scaffold activity; SH3 domain bindingBiological Process: negative regulation of actin filament bundle formation; synapse maturation; olfactory behavior; cytoskeletal anchoring; righting reflex; social behavior; habituation; determination of affect; long-term memory; adult behavior; protein complex assembly; neuromuscular process controlling balance; associative learning
