The SH3GLB1 Polyclonal Antibody (CAB14887) is a crucial tool for researchers studying SH3GLB1, a key player in autophagy and cell survival pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards SH3GLB1 in human samples, making it reliable for Western blot applications. By targeting the SH3GLB1 protein, this antibody allows for the detection and analysis of SH3GLB1 expression in various cell types, facilitating research in the fields of autophagy, cell biology, and cancer.SH3GLB1, also known as Endophilin B1, is involved in the regulation of autophagosome formation and cargo engulfment, essential processes for maintaining cellular homeostasis and response to stress.
Dysregulation of SH3GLB1 has been linked to impaired autophagy and tumorigenesis, highlighting its potential as a therapeutic target for cancer treatment. By delving into the mechanisms and functions of SH3GLB1, researchers can gain insights that may lead to the development of novel treatments for cancer and other diseases related to autophagy dysfunction.
Product Name:
Bif-1 Rabbit Polyclonal Antibody
SKU:
CAB14887
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-365 of human Bif-1 (NP_057093.1).
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51100
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Bif-1 Rabbit pAb (CAB14887) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
