The SH3D19 Polyclonal Antibody (PAC036294) is a highly specific research tool designed for the study of SH3D19, a protein involved in cellular signaling pathways. This antibody, produced in rabbits, has been validated for use in various experimental applications, including Western blotting. By targeting the SH3D19 protein, this antibody allows for the detection and analysis of SH3D19 expression in different cell types, making it a valuable tool for researchers in the fields of cell biology and signal transduction.SH3D19 is known to play a role in intracellular signaling cascades, impacting processes such as cell growth, differentiation, and migration. Its involvement in these pathways makes it a promising target for investigations into diseases like cancer, where aberrant signaling can lead to uncontrolled cell proliferation.
By studying SH3D19 and its functions, researchers can gain insights that may ultimately contribute to the development of novel therapeutic approaches for treating various disorders.Overall, the SH3D19 Polyclonal Antibody (PAC036294) offers a reliable means of investigating the role of SH3D19 in cellular signaling pathways, providing valuable data that can advance our understanding of fundamental biological processes and potentially lead to the discovery of novel treatment strategies.
Antibody Name:
SH3D19 Antibody (PACO36294)
Antibody SKU:
PACO36294
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human SH3 domain-containing protein 19 protein (468-767AA)
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO36294 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO36294 at dilution of 1:100.
Background:
May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Synonyms:
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP), SH3D19
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
