The SH3BP2 Polyclonal Antibody (CAB10243) is specifically designed for research involving the SH3BP2 protein, which plays a role in signaling pathways related to immune responses and bone metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SH3BP2 protein, this antibody enables the detection and analysis of SH3BP2 in various cell types, making it a valuable tool for studies in immunology, bone biology, and related research fields.SH3BP2, also known as SH3 domain-binding protein 2, is a key regulator of immune responses and bone homeostasis.
Dysregulation of the SH3BP2 signaling pathway has been implicated in various diseases, including autoimmune disorders, skeletal dysplasia, and inflammatory conditions. Investigating the function of SH3BP2 holds potential for developing targeted therapies for these diseases by modulating immune and bone metabolism pathways.Overall, the SH3BP2 Polyclonal Antibody is an essential reagent for researchers seeking to deepen their understanding of SH3BP2's role in immune regulation and bone biology, with implications for therapeutic development in a range of disease contexts.
Product Name:
SH3BP2 Rabbit Polyclonal Antibody
SKU:
CAB10243
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 392-561 of human SH3BP2 (NP_001116153.1).
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6452
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SH3BP2 antibody (CAB10243) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
