The SH3BP1 Polyclonal Antibody (PACO59021) is a valuable tool for researchers studying SH3BP1, a protein involved in cellular signaling pathways and regulation functions. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SH3BP1 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in areas such as cell biology, signal transduction, and cancer research.SH3BP1, also known as SH3 domain-binding protein 1, plays a crucial role in cellular processes such as intracellular signaling, cytoskeletal rearrangement, and membrane dynamics.
Its diverse functions make it an intriguing target for research into various diseases and disorders, including cancer, neurodegenerative diseases, and immune disorders. Understanding the role of SH3BP1 can provide valuable insights into the underlying mechanisms of these conditions and potentially lead to the development of targeted therapies.Overall, the SH3BP1 Polyclonal Antibody (PACO59021) offers researchers a reliable tool for investigating the functions and implications of SH3BP1 in various biological contexts, with the potential to advance our understanding of cellular signaling pathways and disease mechanisms.
Antibody Name:
SH3BP1 Antibody (PACO59021)
Antibody SKU:
PACO59021
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human SH3 domain-binding protein 1 protein (161-266AA)
IHC image of PACO59021 diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).
Synonyms:
SH3 domain-binding protein 1, SH3BP1
UniProt Protein Function:
SH3BP1: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; Adaptor/scaffold; GAPsChromosomal Location of Human Ortholog: 22q13.1Molecular Function: protein binding
