The SH2D1A Polyclonal Antibody (CAB1143) is a valuable tool for researchers studying the SH2 domain-containing protein 1A (SH2D1A), a crucial regulator of immune responses. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SH2D1A protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for studies in immunology and cancer research.SH2D1A, also known as SAP (SLAM-associated protein), plays a pivotal role in immune cell signaling and activation, particularly in the context of T-cell function.
Mutations in the SH2D1A gene have been associated with X-linked lymphoproliferative syndrome (XLP), a severe immunodeficiency disorder. Research into SH2D1A function is essential for gaining insights into immune system regulation and developing potential therapies for immunodeficiencies and related disorders.Overall, the SH2D1A Polyclonal Antibody (CAB1143) provides researchers with a reliable tool for investigating the role of SH2D1A in immune system function and its implications for various diseases, paving the way for advancements in the field of immunology.
Product Name:
SH2D1A Rabbit Polyclonal Antibody
SKU:
CAB1143
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human SH2D1A (NP_002342.1).
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4068
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SH2D1A Rabbit pAb (CAB1143) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
