null

SGTA Monoclonal Antibody [PAT19E8AT] (CPAB0651)

SKU:
CPAB0651
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT19E8AT
Applications:
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

SGTA Monoclonal Antibody [PAT19E8AT] (CPAB0651)

The SGTA Polyclonal Antibody (CPAB0651) is a valuable tool for researchers studying SGTA, a protein involved in protein folding and quality control in the cell. This antibody, raised in rabbits, is highly specific for detecting SGTA in human samples and is validated for use in Western blotting and immunohistochemistry applications. By targeting SGTA, researchers can easily visualize and study the protein in various cell types, making it an essential component for studies in cell biology and protein quality control mechanisms.SGTA, also known as small glutamine-rich tetratricopeptide repeat-containing protein alpha, plays a crucial role in maintaining protein homeostasis and preventing the accumulation of misfolded proteins in the cell.

Dysregulation of SGTA has been implicated in various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular function. By understanding the role of SGTA, researchers can develop targeted therapies that modulate protein folding pathways and potentially treat diseases associated with protein misfolding.

Product Name:SGTA Antibody
Product Sku:CPAB0651
Size:5μg
Host Species:Mouse
Immunogen:Anti-human SGTA mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SGTA protein 1-313 amino acids purified from Ecoli.
Clone:PAT19E8AT.
Reactivity:Other bodies
Applications:ELISA, Flow Cytometry
Purification Method:SGTA antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:SGTA is a ubiquitously expressed protein that contains three TPR protein-protein interaction duplicates. SGTA takes part as a component of the androgen receptor (AR)-chaperone-cochaperone complex, functions as a cochaperone and participates in androgen signaling. SGTA binds directly to HSC70 and HSP70 and mediates their ATPase activity. SGTA gene encodes a protein that is able to interact with the chief nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate. In addition, SGTA interacts with Vpu and Gag from HIV-1, SARS-CoV accessory protein 7a, DNAJC5 and DNAJC5B. Since this transcript is expressed universally in several tissues, SGTA serves a housekeeping function. While being involved in apoptosis and androgen signaling, SGTA is a possible molecule for polycystic ovary syndrome, a disorder characterized by androgen excess, obesity and menstrual disturbances.
Synonyms:alphaSGT, hSGT, SGT, Vpu-binding protein, UBP, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, SGT1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

Related Products