The SGPL1 Polyclonal Antibody (CAB15745) is a vital tool for researchers studying sphingosine-1-phosphate lyase 1 (SGPL1), an enzyme involved in sphingolipid metabolism and cellular signaling pathways. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, and has been validated for use in Western blot applications.SGPL1 plays a key role in the regulation of sphingolipid levels and the generation of bioactive lipid signaling molecules, making it a crucial target for research into cancer, cardiovascular disease, and immune disorders. By binding specifically to the SGPL1 protein, this antibody enables researchers to detect and analyze SGPL1 expression in various cell types, providing valuable insights into its function and potential therapeutic applications.
With its ability to facilitate the investigation of SGPL1 in different biological contexts, the SGPL1 Polyclonal Antibody is an indispensable tool for advancing our understanding of sphingolipid metabolism and its implications for human health. Whether studying cellular stress responses, lipid signaling pathways, or disease mechanisms, this antibody is a valuable asset for researchers in the fields of biochemistry, molecular biology, and drug discovery.
Product Name:
SGPL1 Rabbit Polyclonal Antibody
SKU:
CAB15745
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_003892.2).
Endoplasmic reticulum membrane, Single-pass type III membrane protein.
Calculated MW:
64kDa
Observed MW:
60kDa
Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14.
Purification Method:
Affinity purification
Gene ID:
8879
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SGPL1 Rabbit pAb (CAB15745) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
