The SGF29 Polyclonal Antibody (PAC040122) is a vital tool for researchers studying SGF29, a protein involved in chromatin regulation and gene expression. This antibody, produced in rabbits, exhibits excellent reactivity with human samples and is validated for use in Western blot applications. By binding specifically to SGF29, this antibody enables precise detection and analysis in a variety of cell types, making it an invaluable asset for investigations in the fields of epigenetics and gene regulation.SGF29, a component of the SAGA histone acetyltransferase complex, plays a crucial role in facilitating transcriptional activation and gene expression.
Its involvement in chromatin modifications makes it a key player in regulating cellular processes such as differentiation and development. Research on SGF29 is essential for understanding the mechanisms underlying gene regulation and identifying potential therapeutic targets for diseases related to aberrant gene expression.With its high specificity and reliability, the SGF29 Polyclonal Antibody is an essential tool for researchers exploring the intricate workings of chromatin regulation and gene expression. Its versatility and accuracy make it an indispensable resource for studies in molecular biology, genetics, and epigenetics.
Antibody Name:
SGF29 Antibody (PACO40122)
Antibody SKU:
PACO40122
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human SAGA-associated factor 29 homolog protein (1-293AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO40122 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO40122 at dilution of 1:100.
Background:
Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.
CCDC101: Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation. Belongs to the SGF29 family.Chromosomal Location of Human Ortholog: 16p11.2Molecular Function: methylated histone residue binding; protein binding
UniProt Protein Details:
NCBI Summary:
CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
