The SGCD Polyclonal Antibody (CAB13351) is a vital tool for researchers studying the SGCD gene, which is associated with muscular dystrophy and other muscle-related diseases. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the SGCD protein, this antibody allows for the detection and analysis of SGCD expression in various cell types, making it ideal for investigations in muscle biology and disease pathology.The SGCD gene encodes a protein called delta-sarcoglycan, which is part of a complex of proteins that maintain the structural integrity of muscle fibers. Mutations in the SGCD gene can lead to muscular dystrophy, a group of genetic disorders characterized by muscle weakness and degeneration.
Studying the function and regulation of SGCD is essential for understanding the mechanisms underlying muscular dystrophy and developing potential therapeutic interventions.With its high specificity and sensitivity, the SGCD Polyclonal Antibody (CAB13351) is a valuable tool for researchers seeking to unravel the complexities of muscle disease and advance our knowledge of the molecular pathways involved in muscle function and maintenance. By targeting the SGCD protein, this antibody enables precise detection and analysis of SGCD expression, offering new insights into the pathophysiology of muscular dystrophy and related disorders.
Recombinant fusion protein containing a sequence corresponding to amino acids 61-290 of human Delta-sarcoglycan (Delta-sarcoglycan (SGCD)) (NP_000328.2).
Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytoskeleton, sarcolemma.
Calculated MW:
32kDa
Observed MW:
37-42kDa
The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
6444
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Delta-sarcoglycan (Delta-sarcoglycan (SGCD)) antibody (CAB13351) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
