The SFXN4 Monoclonal Antibody (PAC021880) is a valuable tool for researchers studying SFXN4, a protein involved in mitochondrial function and metabolism. This antibody, produced using hybridoma technology, is highly specific to human SFXN4 and is suitable for use in various experimental techniques, including Western blot and immunofluorescence.SFXN4, a member of the sideroflexin family, plays a vital role in maintaining mitochondrial iron homeostasis and energy metabolism. Dysregulation of SFXN4 has been linked to mitochondrial dysfunction and metabolic disorders, making it an important target for further investigation in metabolic research and related diseases.
By using the SFXN4 Monoclonal Antibody, researchers can effectively detect and study SFXN4 expression and localization in different cell types and tissues. This antibody's high specificity and sensitivity make it a reliable tool for elucidating the functions of SFXN4 in mitochondrial biology and metabolic pathways, potentially leading to new insights and therapeutic strategies in metabolic diseases.
Antibody Name:
SFXN4 Antibody (PACO21880)
Antibody SKU:
PACO21880
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from N-terminal of human SFXN4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen The MGC Project Team, Genome Res. 14:2121-2127(2004).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from HUVEC cells, using SFXN4 antibody.
Synonyms:
Breast cancer resistance marker 1; Sideroflexin-4; BCRM1; SFXN4;
UniProt Protein Function:
SFXN4: Potential iron transporter. Belongs to the sideroflexin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 10q26.11Cellular Component: intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membraneMolecular Function: ion transmembrane transporter activityBiological Process: iron ion homeostasisDisease: Combined Oxidative Phosphorylation Deficiency 18
