The SFTPC Polyclonal Antibody (CAB1835) is specifically designed for research involving the Surfactant Protein C (SFTPC), a key protein involved in lung development and function. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in a variety of research applications, including Western blot analysis. By binding to the SFTPC protein, this antibody allows for the detection and analysis of SFTPC in different cell types, making it an essential tool for studies in pulmonary biology and respiratory diseases.
Surfactant Protein C (SFTPC) is essential for the maintenance of normal lung function, playing a crucial role in lung surfactant production and reducing surface tension in the alveoli. Dysregulation of SFTPC expression or function has been implicated in various lung diseases, including respiratory distress syndrome and interstitial lung diseases. Research into the role of SFTPC in lung physiology and pathology is important for developing new treatment strategies for these respiratory conditions.
Product Name:
SFTPC Rabbit Polyclonal Antibody
SKU:
CAB1835
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 59-197 of human SFTPC (NP_003009.2).
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
6440
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using SFTPC Rabbit pAb (CAB1835) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
