The SFTPC Polyclonal Antibody (CAB11764) is a valuable tool for research studies focusing on the surfactant protein C (SFTPC), a key component of pulmonary surfactant that plays a crucial role in lung function and respiratory health. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.SFTPC is essential for maintaining proper lung compliance and preventing alveolar collapse, making it a critical target for investigation in respiratory diseases such as pulmonary fibrosis, acute respiratory distress syndrome (ARDS), and interstitial lung diseases.
By detecting and analyzing SFTPC expression in various cell types, researchers can gain valuable insights into the molecular mechanisms underlying these conditions.Given the importance of SFTPC in pulmonary health, this antibody is an invaluable tool for researchers seeking to better understand respiratory diseases and develop innovative therapies to improve patient outcomes. Its specificity and sensitivity make it a reliable choice for studies in pulmonology, respiratory medicine, and related areas of research.
Product Name:
SFTPC Rabbit Polyclonal Antibody
SKU:
CAB11764
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 59-197 of human SFTPC (NP_003009.2).
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
6440
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using SFTPC Rabbit pAb (CAB11764) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
