SFTPB Rabbit Polyclonal Antibody (CAB1748)
- SKU:
- CAB1748
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SFTPB Rabbit Polyclonal Antibody |
SKU: | CAB1748 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 94-393 of human SFTPB (NP_000533.3). |
Sequence: | MAKE AIFQ DTMR KFLE QECN VLPL KLLM PQCN QVLD DYFP LVID YFQN QTDS NGIC MHLG LCKS RQPE PEQE PGMS DPLP KPLR DPLP DPLL DKLV LPVL PGAL QARP GPHT QDLS EQQF PIPL PYCW LCRA LIKR IQAM IPKG ALAV AVAQ VCRV VPLV AGGI CQCL AERY SVIL LDTL LGRM LPQL VCRL VLRC SMDD SAGP RSPT GEWL PRDS ECHL CMSV TTQA GNSS EQAI PQAM LQAC VGSW LDRE KCKQ FVEQ HTPQ LLTL VPRG WDAH TTCQ ALGV CGTM SSPL QCIH SPDL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SP-B; PSP-B; SFTB3; SFTP3; SMDP1; SFTPB |
Positive Sample: | Mouse liver,Mouse brain,Rat liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space, surface film. |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
Purification Method: | Affinity purification |
Gene ID: | 6439 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |