The SFTPB Polyclonal Antibody (CAB1748) is a valuable tool for researchers studying the surfactant protein B (SFTPB), a crucial component of lung surfactant that plays a key role in lung function and respiratory health. This polyclonal antibody, generated in rabbits, is highly specific and reacts strongly with human samples, making it an excellent choice for Western blot applications.With its ability to bind to the SFTPB protein, this antibody enables precise detection and analysis of SFTPB in a variety of cell types, making it ideal for use in studies related to pulmonary diseases, lung development, and respiratory physiology.
Understanding the role of SFTPB is essential for research into conditions such as pulmonary surfactant dysfunction and respiratory distress syndromes, paving the way for the development of targeted therapies and treatments.
Product Name:
SFTPB Rabbit Polyclonal Antibody
SKU:
CAB1748
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 94-393 of human SFTPB (NP_000533.3).
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
Purification Method:
Affinity purification
Gene ID:
6439
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SFTPB Antibody (CAB1748) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
