The SFRP1 Polyclonal Antibody (CAB2911) is a valuable tool for researchers studying the secreted frizzled-related protein 1 (SFRP1), a protein involved in Wnt signaling pathways and tumorigenesis. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various research applications including Western blotting.SFRP1 has been shown to act as a tumor suppressor in various cancers, making it a promising target for cancer therapy development. By detecting and analyzing SFRP1 expression levels, researchers can gain insights into the role of this protein in cancer progression, metastasis, and drug resistance mechanisms.
Additionally, SFRP1 has been implicated in other disease processes such as fibrosis, inflammation, and neurodegenerative disorders. By utilizing the SFRP1 Polyclonal Antibody, researchers can further explore the functional relevance of SFRP1 in these pathological conditions, potentially leading to the identification of novel therapeutic targets.Overall, the SFRP1 Polyclonal Antibody (CAB2911) is a reliable tool for investigating the biological functions of SFRP1 in various disease contexts, paving the way for the development of targeted therapies and precision medicine approaches.
Product Name:
SFRP1 Rabbit Polyclonal Antibody
SKU:
CAB2911
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-314 of human SFRP1 (NP_003003.3).
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
Purification Method:
Affinity purification
Gene ID:
6422
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SFRP1 Rabbit pAb (CAB2911) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
