The SFR1 Antibody (PAC059205) is a highly specific and reliable tool for researchers studying SFR1, a protein involved in DNA repair and genome stability. This polyclonal antibody, generated in rabbits, exhibits strong reactivity with human and mouse samples, making it suitable for a wide range of experiments, including Western blotting and immunofluorescence.SFR1 plays a crucial role in maintaining genomic integrity by participating in homologous recombination repair of DNA double-strand breaks. Dysregulation of SFR1 has been implicated in various diseases, including cancer and genetic disorders, highlighting its importance in cellular function and disease development.
By targeting SFR1 with this antibody, researchers can gain insights into its mechanisms of action and potential therapeutic applications in the context of DNA damage and repair pathways.With its high specificity and sensitivity, the SFR1 Antibody (PAC059205) is an essential tool for advancing research in the fields of molecular biology, genetics, and cancer biology. Its ability to detect and quantify SFR1 protein levels in various experimental settings makes it an invaluable resource for unraveling the complexities of DNA repair processes and their impact on human health.
Antibody Name:
SFR1 Antibody (PACO59205)
Antibody SKU:
PACO59205
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Swi5-dependent recombination DNA repair protein 1 homolog protein (5-93AA)
IHC image of PACO59205 diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcriptional modulator for ESR1.
Synonyms:
Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog), SFR1, C10orf78 MEI5 MEIR5
UniProt Protein Function:
SFR1: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Belongs to the SFR1/MEI5 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q25.1Cellular Component: nucleusMolecular Function: protein bindingBiological Process: double-strand break repair via homologous recombination
